NF2/CEN22q FISH Probe
产品名称： NF2/CEN22q FISH Probe
英文名称： NF2/CEN22q FISH Probe
产品编号： FG0003
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152
- 传真 : +886-2-8751-1186
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Labeled FISH probes for identification of gene amplification using Fluoresecent In Situ Hybridization Technique. (Technology)
- Storage Instruction:
- Store at 4°C in the dark.
- Quality Control Testing:
- Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
- Supplied Product:
- DAPI Counterstain (1500 ng/mL ) 250 uL
- Note:
Hybridization position of the probes on the chromosome.-
- Probe 1:
Size:
Fluorophore:
Location: - NF2
Approximately 300kb
Texas Red
22q12.2
- Probe 2:
Size:
Fluorophore:
Location: - CEN22q
Approximately 620kb
FITC
22q11.22
- Probe Gap:
- The gap between two probes is approximately 4,000 kb.
- Origin:
- Human
- Source:
- Genomic DNA
- Regulation Status:
- For research use only (RUO)
- Publication Reference
- 1.
- Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues.
Takeda M, Kasai T, Enomoto Y, Takano M, Morita K, Kadota E, Iizuka N, Maruyama H, Nonomura A.J Clin Pathol. 2012 Jan;65(1):77-82. Epub 2011 Nov 12.
- Applications
- Fluorescent In Situ Hybridization (Cell)
- Protocol Download
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
enlarge this image- Human breast cancer (FFPE) stained with NF2/CEN22q FISH Probe. Human breast cancer showed no NF2 gene amplification.
- Protocol Download
- Application Image
- Fluorescent In Situ Hybridization (Cell)
- Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
- enlarge
- Entrez GeneID:
- 4771
- Gene Name:
- NF2
- Gene Alias:
- ACN,BANF,SCH
- Gene Description:
- neurofibromin 2 (merlin)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq
- Other Designations:
- merlin,moesin-ezrin-radixin like,moesin-ezrin-radizin-like protein,neurofibromin 2,neurofibromin 2 (bilateral acoustic neuroma),schwannomerlin,schwannomin
- Related Disease