FITC标记的p400蛋白抗体
产品名称： FITC标记的p400蛋白抗体
英文名称： Anti-p400/FITC
产品编号： HZ-8279R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-p400/FITC Conjugated antibody
FITC标记的p400蛋白抗体
| 产品编号 | bs-8279R-FITC |
| 英文名称 | Anti-p400/FITC |
| 中文名称 | FITC标记的p400蛋白抗体 |
| 别 名 | CAG repeat protein 32; CAGH32; DKFZP434I225; Domino homolog; E1A binding protein p400; EP 400; EP400; FLJ42018; FLJ45115; hDomino; KIAA1498; KIAA1818; p400 kDa SWI2/SNF2 related protein; P400 SWI2/SNF2-related protein; TNRC12; Trinucleotide repeat containing 12; Trinucleotide repeat containing gene 12 protein; EP400_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 344kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human p400 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: NuAR is a multi-protein histone acetyltransferase complex that functions to acetylate the nucleosomal Histones H4 and H2A, thereby activating transcription of select target genes. p400, also known as EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is a component of the NuAR complex. Expressed in brain, liver, thymus, lung, spleen, colon and kidney, p400 regulates the transcriptional activity of proteins such as MZF-1 and contributes to the ATPase and helicase activities of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A. The ability of p400 to regulate transcriptional and apoptotic activity suggests that the NuAR complex may be a crucial component of cell proliferation, transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due to alternative splicing events. Function: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Subunit: Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. May also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. The NuA4 complex interacts with MYC and the adenovirus E1A protein. EP400 interacts with TRRAP, RUVBL1 and RUVBL2. Interacts with ZNF42. Interacts with PHF5A (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain. Contains 1 Myb-like domain. Database links: Entrez Gene: 57634 Human Entrez Gene: 75560 Mouse Omim: 606265 Human SwissProt: Q96L91 Human SwissProt: Q8C0P6 Mouse SwissProt: Q8CHI8 Mouse Unigene: 306094 Human Unigene: 595201 Human Unigene: 270487 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
NUAR是一种多蛋白组蛋白乙酰转移酶复合物，其功能是乙酰化核小体组蛋白H4和H2A，从而激活选择的靶基因的转录。P400，也称为EP400（E1A结合蛋白P400）或MdMulo，定位于细胞核，是核仁复合体的一个组成部分。在脑、肝、胸腺、肺、脾、结肠和肾脏中表达，P400调节MZF-1等蛋白的转录活性，并参与NUA4的ATP酶和解旋酶活性。P400是一种与腺病毒癌基因E1A相互作用的SWI2/SNF2相关蛋白，从而激活E1A的促凋亡活性，P400调控转录和凋亡活性的能力提示Nuar复合物可能是细胞增殖、转运的重要组成部分。形成和可能的致癌作用。P400的五种异构体由于选择性剪接事件而存在。