AIM2,干扰素诱导蛋白AIM2抗体

产品编号HZ-5986R
英文名称AIM2
中文名称干扰素诱导蛋白AIM2抗体
别 名Absent in melanoma 2; AIM 2; Aim2; AIM2_MOUSE; Interferon-inducible protein AIM2; OTTHUMP00000035296; PYHIN4.
规格价格0.1ml 0.2ml 
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 染色质和核信号 转录调节因子 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
AIM2,干扰素诱导蛋白AIM2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:50-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量40kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from mouse AIM2.
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
AIM2,干扰素诱导蛋白AIM2抗体PubMedPubMed
产品介绍background:
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.

Function:
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.

Subunit:
Self-associates; forms homooligomers in response to cytosolic dsDNA and the dsDNA seems to serve as oligomerization platform. Component of the AIM2 inflammasome complex. Interacts with PYCARD. Interacts with IFI16 (By similarity). Interacts with EIF2AK2/PKR (By similarity).

Subcellular Location:
Nucleus (By similarity). Cytoplasm.

Tissue Specificity:
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis.

Similarity:
Belongs to the HIN-200 family.
Contains 1 DAPIN domain.
Contains 1 HIN-200 domain.

Gene ID:
383619

AIM2,干扰素诱导蛋白AIM2抗体Database links:
Entrez Gene: 9447 Human
Entrez Gene: 383619 Mouse
Entrez Gene: 304987 Rat
Omim: 604578 Human
SwissProt: O14862 Human
SwissProt: Q91VJ1 Mouse
Unigene: 281898 Human
Unigene: 733411 Human
Unigene: 131453 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.