FITC标记的泛素结合酶E2 230K抗体
产品名称： FITC标记的泛素结合酶E2 230K抗体
英文名称： Anti-UBE2O/FITC
产品编号： HZ-8380R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-UBE2O/FITC Conjugated antibody
FITC标记的泛素结合酶E2 230K抗体
| 产品编号 | bs-8380R-FITC |
| 英文名称 | Anti-UBE2O/FITC |
| 中文名称 | FITC标记的泛素结合酶E2 230K抗体 |
| 别 名 | E2 230K; ubiquitin-conjugating enzyme E2O; EC=6.3.2.19; FLJ12878; KIAA1734; Likely Ortholog of Mouse Ubiquitin Conjugating Enzyme; RP23 193A16.5; UBE2O; UBE2O_HUMAN; Ubiquitin carrier protein O; Ubiquitin conjugating enzyme E2 O; ubiquitin conjugating enzyme E2O. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, Chicken, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 141kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human UBE2O/E2 230K |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: UBE20, also known as E2-230K, is a 1,292 amino acid member of the uniquitin-conjugating enzyme family that is involved in protein modification. Expressed predominately in heart and skeletal muscle, UBE2O functions to catalyze the ATP-dependent covalent attachment of ubiquitin to select proteins, thereby targeting the ubiquitinated proteins for proteasomal degradation. The gene encoding UBE2O maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Tissue Specificity: Predominantly expressed in skeletal muscle and heart. Similarity: Belongs to the ubiquitin-conjugating enzyme family. Database links: Entrez Gene: 63893 Human Entrez Gene: 217342 Mouse SwissProt: Q9C0C9 Human SwissProt: Q6ZPJ3 Mouse Unigene: 16130 Human Unigene: 243950 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
UBE20，也称为E2-230K，是参与蛋白质修饰的单胍缀合酶家族的1292氨基酸成员。UBE2O主要在心脏和骨骼肌中表达，催化泛素的ATP依赖性共价连接以选择蛋白质，从而靶向泛素化蛋白降解蛋白酶体。编码UBE2O的基因映射到人类17号染色体，其包含超过2.5%的人类基因组并编码超过1200个基因。两个关键的肿瘤抑制基因与17号染色体相关，即p53和BRCA1。肿瘤抑制基因p53是通过维持细胞命运通过DNA修复与细胞死亡来维持细胞遗传完整性所必需的。p53表达的异常或丢失与恶性细胞生长和Li Fraumeni综合征有关。与p53一样，BRCA1直接参与DNA修复，尽管具体而言，它被认为是早发性乳腺癌和卵巢癌、结肠癌、前列腺癌和输卵管癌易感性的遗传决定因素。