RIMS4,神经元突触膜胞外分泌调节蛋白4抗体

产品编号HZ-11360R
英文名称RIMS4
中文名称神经元突触膜胞外分泌调节蛋白4抗体
别 名C20orf190; dJ781B1.3; Rab3-interacting molecule 4; regulating synaptic membrane exocytosis 4; Regulating synaptic membrane exocytosis protein 4; RIM 4; RIM4 gamma; Rims4; RIMS4_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
RIMS4,神经元突触膜胞外分泌调节蛋白4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量29kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human RIMS4
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
RIMS4,神经元突触膜胞外分泌调节蛋白4抗体PubMedPubMed
产品介绍background:
Rim4 (Rab 3 interacting molecule 4), also known as Rim4 or regulating synaptic membrane exocytosis protein 4, is a 269 amino acid protein that localizes to the cell junction and regulates synaptic membrane exocytosis. Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis. Rab 3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (Rab 3 interacting molecule), a putative effector protein for Rab 3 proteins, is thought to regulate neutrotransmitter release through its interaction with Rab 3 and other synaptic proteins.

Function:
Regulates synaptic membrane exocytosis.

Subunit:
Binds PPFIA3 (By similarity). Does not bind RAB3.

Subcellular Location:
Cell junction; synapse.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 C2 domain.

RIMS4,神经元突触膜胞外分泌调节蛋白4抗体Database links:
UniProtKB/Swiss-Prot: Q9NYW1.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.