Uniprot ID:Q9UBW8
Species Reactivity:Human,mouse;Other species are not tested.Please decide the specificity by homology
Antibody type:Polyclonal Antibody
Aliases:SGN7a,Signalosome subunit 7a,Dermal papilla-derived protein 10,JAB1-containing signalosome subunit 7a,COPS7A,CSN7A, DERP10Raised in:Rabbit
Background\Function :Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Stroage Buffer:Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purity:Caprylic Acid Ammonium Sulfate Precipitation purified
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