FITC标记的脱氢酶/还原酶家族成员2抗体
产品名称： FITC标记的脱氢酶/还原酶家族成员2抗体
英文名称： Anti-DHRS2/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-DHRS2/FITC Conjugated antibody
FITC标记的脱氢酶/还原酶家族成员2抗体
| 产品编号 | bs-8573R-FITC |
| 英文名称 | Anti-DHRS2/FITC |
| 中文名称 | FITC标记的脱氢酶/还原酶家族成员2抗体 |
| 别 名 | Dehydrogenase/reductase (SDR family) member 2; Dehydrogenase/reductase member 2; Dehydrogenase/reductase SDR family member 2; Dicarbonyl reductase HEP27; DHRSⅡ; Hep27; HEP27 protein; Protein D; SDR family member; SDR25C1; Short chain alcohol dehydrogenase family member; Short chain dehydrogenase/reductase family 25C member 1; DHRS2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 27kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DHRS2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: DHRS2 is a 258 amino acid protein that localizes to the nucleus and belongs to the short-chain dehydrogenase/reductase (SDR) family. Functioning as an NADPH-dependent dicarbonyl reductase, DHRS2 is thought to inhibit cell replication by either converting cortisone in cortisol, or by catalyzing the oxidation of androgen and estrogen. The gene encoding DHRS2 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. Function: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication. Subcellular Location: Nucleus. Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. Database links: Entrez Gene: 10202 Human Entrez Gene: 71412 Mouse Entrez Gene: 691464 Rat SwissProt: Q13268 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
DRS2是一个258个氨基酸的蛋白质，定位于细胞核，属于短链脱氢酶/还原酶（SDR）家族。DHS2作为NADPH依赖的二羰基还原酶，被认为通过在皮质醇中转化可的松或通过催化的氧化来抑制细胞复制。编码DHS2的基因映射到人类14号染色体，该基因含有700个以上的基因，并包含人类基因组的近3.5%。第14号染色体编码了早老素1（PSEN1）基因，这是与阿尔茨海默病（AD）发展相关的三个关键基因之一。SerpIA1基因也位于14号染色体上，当有缺陷时，会导致遗传障碍？抗胰蛋白酶缺乏症，表现为严重的肺部并发症和肝功能不全。