FITC标记的富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体
产品名称： FITC标记的富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体
英文名称： Anti-LRRK1/FITC
产品编号： HZ-18418R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-LRRK1/FITC Conjugated antibody
FITC标记的富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体
| 英文名称 | Anti-LRRK1/FITC |
| 中文名称 | FITC标记的富含亮氨酸重复丝氨酸/苏氨酸蛋白激酶1抗体 |
| 别 名 | KIAA1790; Leucine rich repeat serine/threonine protein kinase 1; Leucine-rich repeat serine/threonine-protein kinase 1; LRRK 1; Lrrk1; LRRK1_HUMAN; RIPK6; Roco1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 神经生物学 信号转导 细胞凋亡 G蛋白偶联受体 细胞分化 G蛋白信号 Alzheimer's |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 225kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LRRK1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. LRRK1 (leucine-rich repeat serine/threonine-protein kinase 1), also known as RIPK6, Roco1 or KIAA1790, is a 2,038 amino acid cytoplasmic protein that contains one protein kinase domain, four ANK repeats and 11 leucine-rich repeats and belongs to the Ser/Thr protein kinase family. Using magnesium as a cofactor, LRRK1 catalyzes the ATP-dependent phosphorylation of target proteins. The gene encoding LRRK1, which is expressed as four alternatively spliced isoforms, is thought to be involved in the pathogenesis of Parkinson's disease. Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. Contains 4 ANK repeats. Contains 13 LRR (leucine-rich) repeats. Contains 1 protein kinase domain. Contains 1 Roc domain. Database links: Entrez Gene: 79705 Human Entrez Gene: 233328 Mouse Entrez Gene: 308703 Rat Omim: 610986 Human SwissProt: Q38SD2 Human SwissProt: Q3UHC2 Mouse Unigene: 407918 Human Unigene: 33284 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
蛋白质在丝氨酸和苏氨酸残基上的磷酸化和去磷酸化是调节真核生物广泛细胞功能的重要手段，包括细胞分裂、稳态和凋亡。一组紧密参与这一过程的蛋白质是丝氨酸/苏氨酸（SE/THR）蛋白激酶。LRRK1（富含亮氨酸的重复序列丝氨酸/苏氨酸蛋白激酶1）又称RIPK6、Roco1或KIAA1790，是一种2038氨基酸胞质蛋白，含有一个蛋白激酶结构域、4个ANK重复序列和11个富含亮氨酸的重复序列，属于Ser/Thr蛋白激酶家族。利用镁作为辅因子，LRRK1催化靶蛋白的ATP依赖性磷酸化。编码LRRK1的基因被表达为四种可选择的剪接异构体，被认为与帕金森病的发病机制有关。