FITC标记的血红素转运蛋白1抗体
产品名称： FITC标记的血红素转运蛋白1抗体
英文名称： Anti-HCP1/FITC
产品编号： HZ-15428R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-HCP1/FITC Conjugated antibody
FITC标记的血红素转运蛋白1抗体
| 英文名称 | Anti-HCP1/FITC |
| 中文名称 | FITC标记的血红素转运蛋白1抗体 |
| 别 名 | G21; HCP 1; Heme Carrier Protein 1; MGC9564; PCFT; PCFT/HCP1; PCFT_HUMAN; PDE7A; Proton coupled folate transporter; Proton-coupled folate transporter; SLC46A1; Solute carrier family 46 member 1; |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 免疫学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HCP1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013] Function: Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. Subcellular Location: Apical cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Localizes to the apical membrane of intestinal cells in iron-deficient cells, while it resides in the cytoplasm in iron-replete cells. Tissue Specificity: Expressed in kidney, liver, placenta, small intestine, spleen, retina and retinal pigment epithelium. Lower levels found in colon and testis. Very low levels in brain, lung, stomach, heart and muscle. In intestine, expressed in duodenum with lower levels in jejunum, ileum, cecum, rectum and segments of the colon. DISEASE: Hereditary folate malabsorption (HFM) [MIM:229050]: Rare autosomal recessive disorder characterized by impaired intestinal folate absorption with folate deficiency resulting in anemia, hypoimmunoglobulinemia with recurrent infections, and recurrent or chronic diarrhea. In many patients, neurological abnormalities such as seizures or mental retardation become apparent during early childhood, attributed to impaired transport of folates into the central nervous system. When diagnosed early, the disorder can be treated by administration of folate. If untreated, it can be fatal and, if treatment is delayed, the neurological defects can become permanent. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the major facilitator superfamily. SLC46A family. Database links: Entrez Gene: 5781 Human Entrez Gene: 19247 Mouse Entrez Gene: 25622 Rat Omim: 176876 Human SwissProt: Q06124 Human SwissProt: P35235 Mouse SwissProt: P41499 Rat Unigene: 506852 Human Unigene: 474046 Mouse Unigene: 8681 Mouse Unigene: 98209 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码跨膜质子偶联的叶酸转运蛋白，该蛋白促进叶酸和抗叶酸底物在细胞膜上的移动，最适宜在酸性pH环境中。这种蛋白质也在脑和脉络丛中表达，它将叶酸转运到中枢神经系统。该蛋白还作为血红素转运体在十二指肠肠细胞，并可能在其他组织，如肝脏和肾脏。它的定位到顶端膜或细胞质的肠细胞是由膳食铁水平调制。该基因突变与常染色体隐性遗传性叶酸吸收不良疾病有关。另一种编码不同的异构体的剪接转录变体已被描述为该基因。[ RefSeq，Aug 2013提供]