Big endothelin-1,内皮素-1抗体

产品编号HZ-0188R
英文名称Big endothelin-1
中文名称内皮素-1抗体
别 名EDN1_HUMAN; Big endothelin 1; EDN 1; EDN1; EDN1 protein; Endothelin1; Endothelin 1; Endothelin-1; ET 1; ET1; OTTHUMP00000039245; PPET1; Preproendothelin 1; Preproendothelin1.
说 明 书0.1ml 0.2ml
研究领域心血管 神经生物学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
Big endothelin-1,内皮素-1抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量22kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Big endothelin-1
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Big endothelin-1,内皮素-1抗体PubMedPubMed
产品介绍background:
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms - ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart, and liver. Endothelin 1 is expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.

Function:
Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells.

Similarity:
Belongs to the endothelin/sarafotoxin family.

Gene ID:
1906

Big endothelin-1,内皮素-1抗体Database links:
Entrez Gene: 1906 Human
Entrez Gene: 13614 Mouse
Entrez Gene: 24323 Rat
Omim: 131240 Human
SwissProt: P05305 Human
SwissProt: P22387 Mouse
SwissProt: P22388 Rat
Unigene: 511899 Human
Unigene: 713645 Human
Unigene: 10918 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

内皮素(Endothelin，ET)是一种强的血管收缩剂，分为ET-1,ET-2,ET-3 三种，ET-1主要在内皮细胞中表达,而ET-2和ET-3则主要在神经系统中表达。ET具有广泛的生物学作用。此抗体是ET-1特异性抗体，与ET-2,ET-3无交叉反应。