Erbin,Erbin蛋白抗体

产品编号HZ-20310R
英文名称Erbin
中文名称Erbin蛋白抗体
别 名Densin-180-like protein; Erbb2-interacting protein; ERBB2IP; Erbin; LAP2; LAP2_HUMAN; Protein LAP2.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 G蛋白信号
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Horse, Rabbit,
Erbin,Erbin蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量158kDa
细胞定位细胞核 细胞外基质
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Erbin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Erbin,Erbin蛋白抗体PubMedPubMed
产品介绍background:
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Function:
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state

Subunit:
Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST Isoform 3 (via N-terminus).

Subcellular Location:

Erbin,Erbin蛋白抗体Tissue Specificity:
Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.

Similarity:
Belongs to the LAP (LRR and PDZ) protein family.
Contains 17 LRR (leucine-rich) repeats.
Contains 1 PDZ (DHR) domain.

Gene ID:
55914

Database links:
Entrez Gene: 55914 Human
Entrez Gene: 59079 Mouse
Omim: 606944 Human
SwissProt: Q96RT1 Human
SwissProt: Q80TH2 Mouse
Unigene: 519346 Human
Unigene: 591774 Human
Unigene: 597241 Human
Unigene: 277354 Mouse

Erbin,Erbin蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.