FITC标记的细胞表面趋化因子受体8抗体
产品名称： FITC标记的细胞表面趋化因子受体8抗体
英文名称： Anti-CCR8/FITC
产品编号： HZ-10678R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
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- 邮编 : 200612
- 所在区域 : 上海
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Rabbit Anti-CCR8/FITC Conjugated antibody
FITC标记的细胞表面趋化因子受体8抗体
| 英文名称 | Anti-CCR8/FITC |
| 中文名称 | FITC标记的细胞表面趋化因子受体8抗体 |
| 别 名 | C-C chemokine receptor 8; C-C chemokine receptor type 8;CCR-8; C-C CKR-8; CC-CKR-8; CCR8; CD_antigen=CDw198.GPR-CY6; GPRCY6; Chemokine receptor-like 1; CKR-L1; TER1; CMKBRL2; CC-chemokine receptor CHEMR1; CMKBR8; CKRL1; CCR8_MOUSE. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞膜受体 趋化因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CCR8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4°C. |
| 产品介绍 | background: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation regulated cytokine (TARC) and macrophage inflammatory protein 1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes. CCR8 is also believed to be alternative coreceptor with CD4 for HIV-1 infection. Function: Receptor for the CCL1/SCY1/TCA-3 chemokine. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in thymus. Similarity: Belongs to the G-protein coupled receptor 1 family. Database links: Entrez Gene: 1237 Human Entrez Gene: 12776 Mouse Omim: 601834 Human SwissProt: P51685 Human SwissProt: P56484 Mouse Unigene: 113222 Human Unigene: 442098 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因编码β趋化因子受体家族的成员，该家族被预测为类似于G蛋白偶联受体的七种跨膜蛋白。趋化因子及其受体是重要的各种细胞类型的迁移到炎症部位。这种受体蛋白优先在胸腺中表达。I-309、胸腺激活调节细胞因子（TARC）和巨噬细胞炎症蛋白1β（MIP1β）已被鉴定为该受体的配体。该受体及其配体的研究提示其在调节单核细胞趋化和胸腺细胞凋亡中的作用。更具体地说，这种受体可能有助于活化的T细胞在抗原攻击位点和淋巴组织特异性区域内的适当定位。该基因位于趋化因子受体基因簇区。CCR8在脾脏和胸腺、自然杀伤细胞、单核细胞和T细胞中表达，在外周血白细胞中表达水平较低。CCR8也被认为是HIV感染的CD4受体。