分子量:61.6 kDa

纯度:>90% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human IL-1RL1, Fc Tag by the LAL method.

Buffer:50 mM tris, 100 mM glycine, pH7.5

生物活性:Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL33 at 10 μg/mL (100 μl/well) can bind Human IL-1RL1, Fc Tag with a linear range of 0.3-5 μg/mL.

产品特性:Human IL-1RL1, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 61.6 kDa. The predicted N-terminus is Lys 19. The reducing (R) protein migrates as 85-100 kDa in SDS-PAGE  due to glycosylation.

产品背景:Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.