FITC标记的KPNA3蛋白抗体
产品名称： FITC标记的KPNA3蛋白抗体
英文名称： Anti-KPNA3/FITC
产品编号： HZ-16803R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-KPNA3/FITC Conjugated antibody
FITC标记的KPNA3蛋白抗体
| 英文名称 | Anti-KPNA3/FITC |
| 中文名称 | FITC标记的KPNA3蛋白抗体 |
| 别 名 | SRP1 gamma; hSRP1; IMA3_HUMAN; Importin alpha 3; Importin alpha 3 subunit; Importin alpha 4; Importin alpha Q2; Importin subunit alpha-3; IPOA4; Karyopherin alpha 3; Karyopherin alpha 3 importin alpha 4; Karyopherin alpha 3 subunit; Karyopherin subunit alpha 3; Karyopherin subunit alpha-3; KPNA 3; Kpna3; Qip2; SRP1; SRP1 gamma; SRP1-gamma; SRP1gamma; SRP4. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rhesus monkey |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 58kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human KPNA3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009] Function: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. Highest levels in heart and skeletal muscle. Similarity: Belongs to the importin alpha family. Contains 10 ARM repeats. Contains 1 IBB domain. Database links: Entrez Gene: 3839 Human Entrez Gene: 418870 Chicken Entrez Gene: 540719 Cow Entrez Gene: 16648 Mouse Entrez Gene: 396715 Pig Entrez Gene: 361055 Rat Entrez Gene: 706925 Rhesus monkey Omim: 601892 Human SwissProt: O00505 Human SwissProt: O35344 Mouse Unigene: 527919 Human Unigene: 25548 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在真核细胞中，分子在细胞核和细胞质之间的运输是由核孔复合物（NPC）介导的，NPC由60-100种蛋白质组成。小分子（高达70kD）可以通过非选择性扩散穿过核孔，而大分子则通过活性过程运输。该基因编码的蛋白属于进口蛋白家族，参与细胞核蛋白质的导入。[ RefSeq，2009月1日]