FITC标记的胰岛素样生长因子ⅡmRNA结合蛋白2抗体
产品名称： FITC标记的胰岛素样生长因子ⅡmRNA结合蛋白2抗体
英文名称： Anti-IGF2BP2/FITC
产品编号： HZ-8559R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-20
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Rabbit Anti-IGF2BP2/FITC Conjugated antibody
FITC标记的胰岛素样生长因子ⅡmRNA结合蛋白2抗体
| 产品编号 | bs-8559R-FITC |
| 英文名称 | Anti-IGF2BP2/FITC |
| 中文名称 | FITC标记的胰岛素样生长因子ⅡmRNA结合蛋白2抗体 |
| 别 名 | Hepatocellular carcinoma autoantigen p62; IF2B2_HUMAN; IGF 2 mRNA binding protein 2; IGF II mRNA binding protein 2; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; Igf2bp2; IMP 2; IMP-2; IMP2; Insulin like growth factor 2 mRNA binding protein 2; Insulin-like growth factor 2 mRNA-binding protein 2; p62; VICKZ family member 2; VICKZ2; IGF2-BP2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 66kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGF2BP2/IMP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: IGF2BP2 (insulin-like growth factor 2 mRNA binding protein 2) is also known as IGF2 mRNA-binding protein 2, IMP-2 (IGF-II mRNA-binding protein 2), VICKZ family member 2 or hepatocellular carcinoma autoantigen p62 and is a 556 amino acid protein. IGF2BP2 is expressed in a variety of tissues including heart, placenta, skeletal muscle, pancreas, fetal liver, lung, kidney, thymus and gonadal cells. IGF2BP2 is an RNA binding protein which may be involved in the regulation of mRNA translation and may also function to control the spatial localization of target mRNAs. Antibodies against IGF2BP2 have been detected in patients with HCC (hepatocellular carcinoma), suggesting that IGF2BP2 may have a role in the pathogenesis of HCC. Defects in IGF2BP2 are thought to be associated with susceptibility to type 2 diabetes mellitus. Function: Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. May regulate translation of target mRNAs. Subunit: Interacts with HNRPD and IGF2BP1. Subcellular Location: Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. Tissue Specificity: Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis. Similarity: Belongs to the RRM IMP/VICKZ family br>Contains 4 KH domains. Contains 2 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 10644 Human Entrez Gene: 319765 Mouse Entrez Gene: 303824 Rat Omim: 608289 Human SwissProt: Q9Y6M1 Human SwissProt: Q5SF07 Mouse Unigene: 35354 Human Unigene: 489442 Mouse Unigene: 17318 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
IGF2BP2（胰岛素样生长因子2 mRNA结合蛋白2）也被称为IGF2 mRNA结合蛋白2、IMP-2（IGF-II mRNA结合蛋白2）、VICZ家族成员2或肝细胞癌自身抗原p62，并且是556氨基酸蛋白。IGF2BP2在多种组织中均有表达，包括心脏、胎盘、骨骼肌、胰腺、胎肝、肺、肾、胸腺和性腺细胞。IGF2BP2是一种RNA结合蛋白，可能参与mRNA翻译的调控，也可能起到控制靶基因mRNA空间定位的作用。IGF2BP2抗体已被检测到在肝癌患者（肝癌），表明IGF2BP2可能在肝癌的发病机制中发挥作用。IGF2BP2的缺陷被认为与2型糖尿病的易感性有关。