FITC标记的整合素样金属蛋白酶与凝血酶1型抗体
产品名称： FITC标记的整合素样金属蛋白酶与凝血酶1型抗体
英文名称： Anti-ADAMTS1/FITC
产品编号： HZ-1208R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-ADAMTS1/FITC Conjugated antibody
FITC标记的整合素样金属蛋白酶与凝血酶1型抗体
| 英文名称 | Anti-ADAMTS1/FITC |
| 中文名称 | FITC标记的整合素样金属蛋白酶与凝血酶1型抗体 |
| 别 名 | A disintegrin and metalloproteinase with thrombospondin motifs 1; A disintegrin like and metalloprotease with thrombospondin type 1 motif 1; A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 1; ADAM metallopeptidase with thrombospondin type 1 motif 1; ADAM TS 1; ADAM TS1; ADAMTS 1; ADAMTS; C3 C5; KIAA1346; METH 1; METH1. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 心血管 细胞生物 信号转导 细胞类型标志物 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 106kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse ADAMTS1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ADAMTS1 is a metalloproteinase of the ADAM (A Disintegrin And Metalloproteinase) family containing disintegrin-like domains. ADAMTS1, also known as METH1, was first described as a protein elevated in invasive mouse tumors. Initial findings indicated a role for ADAMTS1 in tumor progression, since the protein was preferentially expressed in more invasive tumor cell lines. ADAMTS1 is necessary for normal growth, fertility, and organ morphology and function. Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. Subcellular Location: Secreted > extracellular space > extracellular matrix. Post-translational modifications: The precursor is cleaved by a furin endopeptidase. Similarity: Contains 1 disintegrin domain. Contains 1 peptidase M12B domain. Contains 3 TSP type-1 domains. Database links: Entrez Gene: 9510 Human Entrez Gene: 11504 Mouse Entrez Gene: 79252 Rat Omim: 605174 Human SwissProt: Q9UHI8 Human SwissProt: P97857 Mouse SwissProt: Q9WUQ1 Rat Unigene: 643357 Human Unigene: 8230 Human Unigene: 1421 Mouse Unigene: 7897 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ADAMTS1是亚当（解体蛋白和金属蛋白酶）家族的金属蛋白酶，含有整合素样结构域。ADAMTS1，也称为MYT1，最初被描述为在侵袭性小鼠肿瘤中升高的蛋白质。初步发现表明ADAMTS1在肿瘤进展中起作用，因为该蛋白优先表达于侵袭性更强的肿瘤细胞系。ADAMTS1是正常生长、生育和器官形态和功能所必需的。