FITC标记的线粒体内膜转位同源蛋白22抗体
产品名称： FITC标记的线粒体内膜转位同源蛋白22抗体
英文名称： Anti-TIMM22/FITC
产品编号： HZ-19931R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TIMM22/FITC Conjugated antibody
FITC标记的线粒体内膜转位同源蛋白22抗体
| 英文名称 | Anti-TIMM22/FITC |
| 中文名称 | FITC标记的线粒体内膜转位同源蛋白22抗体 |
| 别 名 | Mitochondrial import inner membrane translocase subunit Tim22; Putative membrane protein; Testis expressed sequence 4; TEX 4; TEX4; TIM 22; TIM22; TIMM 22; Translocase of inner mitochondrial membrane 22 homolog. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 20kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIMM22 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: TIMM22 is an essential core component of the TIM22 protein insertion complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated, signal-gated hydrophilic high-conductance channel. It forms a twin-pore translocase that uses the membrane potential as an external driving force in 2 voltage-dependent steps. Function: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). Subunit: Component of the TIM22 complex, whose core is composed of TIMM22, associated with peripheral protein FXC1/TIM10B and the 70 kDa heterohexamer. In most cases, the 70 kDa complex is composed of TIMM9 and TIMM10. A small fraction of the 70 kDa complex is composed of TIM8 (TIMM8A/DDP1 or TIMM8B/DDP2) and TIMM13. Interacts directly with TIMM9, TIMM10/TIM10A and FXC1/TIM10B. Subcellular Location: Mitochondrion inner membrane; Multi-pass membrane protein. Similarity: Belongs to the Tim17/Tim22/Tim23 family. Database links: Entrez Gene: 29928 Human Entrez Gene: 56322 Mouse Entrez Gene: 79463 Rat Omim: 607251 Human SwissProt: Q9Y584 Human SwissProt: Q9CQ85 Mouse SwissProt: Q9JKW1 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
TIMM22是TIM22蛋白插入复合物的重要核心成分，该复合物介导多路跨膜蛋白输入和插入线粒体内膜。在TIM22复合物中，它构成了电压激活的、信号门控的亲水高电导通道。它形成双孔转位酶，使用膜电位作为2个电压依赖性步骤中的外部驱动力。