分子量:44.8 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human B7-H5, Fc Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human B7-H5, Fc Tag is fused with a human IgG1 Fc tag at the C-terminus, and has a calculated MW of 44.8 kDa. The predicted N-terminus is Phe 33. The reducing (R) protein migrates as 55-60 kDa in SDS-PAGE  due to Glycosylation.

产品背景:Platelet receptor Gi24, also known as B7-H5 and stress-induced secreted protein-1 (Sisp-1), is a protein that in humans is encoded by the C10orf54 gene, which contains 1 Ig-like (immunoglobulin-like) domain. As for C10orf54 gene, C10orf54 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state on ESCs. Human C10orf54 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment.