FITC标记的胞吞再循环相关衔接蛋白CENTB1抗体
产品名称： FITC标记的胞吞再循环相关衔接蛋白CENTB1抗体
英文名称： Anti-CENTB1/ACAP1/FITC
产品编号： HZ-13843R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-CENTB1/ACAP1/FITC Conjugated antibody
FITC标记的胞吞再循环相关衔接蛋白CENTB1抗体
| 英文名称 | Anti-CENTB1/ACAP1/FITC |
| 中文名称 | FITC标记的胞吞再循环相关衔接蛋白CENTB1抗体 |
| 别 名 | ACAP 1; ACAP1; ACAP1_HUMAN; ANK repeat and PH domain-containing protein 1; Arf GAP with coiled coil ANK repeat and PH domains 1; Arf GAP with coiled coil, ankyrin repeat, and pleckstrin homology domains 1; Arf-GAP with coiled-coil; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; ArfGAP with coiled-coil, ankyrin repeat and PH domains 1; CENT B1; Centaurin beta 1; Centaurin-beta-1; CENTB 1; Cnt b1; Cnt-b1; Cntb1; KIAA0050. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 81kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CENTB1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: ACAP1 is a member of the ADP ribosylation factor family of ARF6 GTPase-activating proteins (GAP). GAPs are important regulators of Arf function by controlling the return of ARF to its inactive state. ACAP1 is related to AGAP1 and ASAP1, and all three proteins are similarly expressed in fibroblast cells such as NIH/3T3. Internalization and recycling of integrin receptors is important in cell adhesion and migration modulation, and once inside a cell, proteins and membranes are transported to the endosome where they are sorted for recycling or degradation. ACAP1 promotes cargo sorting by associating directly to recycling cargo proteins. Preventing this interaction inhibits protein recycling. ACAP1 binds transferrin receptors, promoting their transport to the plasma membrane from the endosome. Akt induced phosphorylation of ACAP1 at Ser 554 regulates ACAP1 interaction to integrin in endosomes, and downregulation of Akt or ACAP1 may inhibit cell migration on Fibronectin. Function: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Tissue Specificity: Highest level in lung and spleen. Low level in heart, kidney, liver and pancreas. Post-translational modifications: Phosphorylation at Ser-554 by PKB is required for interaction with ITGB1, export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration. Similarity: Contains 3 ANK repeats. Contains 1 Arf-GAP domain. Contains 1 BAR domain. Contains 1 PH domain. Database links: Entrez Gene: 9744 Human Entrez Gene: 216859 Mouse Omim: 607763 Human SwissProt: Q15027 Human SwissProt: Q8K2H4 Mouse Unigene: 337242 Human Unigene: 288671 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
ACAP1是ARF6 GTP酶活化蛋白（GAP）的ADP-核糖基化因子家族的成员。间隙是ARF功能的重要调节器，通过控制ARF恢复到其非活动状态。ACAP1与AgAP1和AsAP1有关，所有三种蛋白在NIH/3T3等成纤维细胞中表达相似。整合素受体的内化和再循环在细胞粘附和迁移调节中起着重要作用，一旦进入细胞内，蛋白质和膜被运输到内体，在那里它们被分类用于再循环或降解。ACAP1通过直接与回收的货物蛋白相关联来促进货物分拣。防止这种相互作用抑制蛋白质的回收利用。ACAP1结合转铁蛋白受体，促进其从内涵体转运到质膜。Akt诱导的ACAP1在Ser 554磷酸化调节ACAP1与整合素的相互作用，Akt或ACAP1下调可能抑制纤维连接蛋白上的细胞迁移。