FITC标记的紧密连接蛋白7抗体
产品名称： FITC标记的紧密连接蛋白7抗体
英文名称： Anti-Claudin 7/FITC
产品编号： HZ-8482R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-Claudin 7/FITC Conjugated antibody
FITC标记的紧密连接蛋白7抗体
| 英文名称 | Anti-Claudin 7/FITC |
| 中文名称 | FITC标记的紧密连接蛋白7抗体 |
| 别 名 | CEPTR L2; CEPTRL 2; CEPTRL2; Claudin 1; Claudin-7; Claudin1; Claudin7; CLD7_HUMAN; CLDN 7; CLDN-7; CLDN7; Clostridium perfringens enterotoxin receptor like 2; CPETR L2; CPETRL 2; CPETRL2; Hs.84359. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞粘附分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 22kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Claudin 7 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (5). mRNA studies indicate that Claudin-7 is specifically expressed in mouse lung and kidney, but not in heart, brain, spleen, liver, skeletal muscle or testis (6). The gene encoding human Claudin-7 maps to chromosome 17p13 (7). Function: Plays a major role in tight junction-specific obliteration of the intercellular space. Subunit: Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 (By similarity). The phosphorylated form interacts with EPCAM. Subcellular Location: Cell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction. Tissue Specificity: Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions. Post-translational modifications: Phosphorylated. Similarity: Belongs to the claudin family. Database links: Entrez Gene: 1366 Human Entrez Gene: 53624 Mouse Entrez Gene: 65132 Rat Omim: 609131 Human SwissProt: O95471 Human SwissProt: Q9Z261 Mouse SwissProt: Q9Z1L1 Rat Unigene: 513915 Human Unigene: 281896 Mouse Unigene: 32259 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
Claudin超家族由许多与结构相关的蛋白组成（1）。这些蛋白是细胞旁转运（1,2）中紧密连接的重要结构和功能组分。在所有紧密连接的组织中，Caldin均位于上皮细胞和内皮细胞中（1）。已知有三类蛋白质定位于紧密连接，包括克劳丁、闭锁素和结合粘附分子(3)。由四个跨膜结构域和两个胞外环组成的紧密连接蛋白构成紧密连接链（4）。Claudin的表达被高度限制于不同组织的特定区域，并且可能在通过紧密连接的跨细胞转运中起重要作用。mRNA研究表明，Claudin-7在小鼠肺和肾脏中特异性表达，而在心脏、大脑、脾脏、肝脏、骨骼肌或睾丸中无表达。编码人CalDUB-7的基因定位于染色体17p13（7）。