FITC标记的脑衰蛋白反应调节蛋白4抗体
产品名称： FITC标记的脑衰蛋白反应调节蛋白4抗体
英文名称： Anti-CRMP4/FITC
产品编号： HZ-8285R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
上海沪震实业有限公司
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Rabbit Anti-CRMP4/FITC Conjugated antibody
FITC标记的脑衰蛋白反应调节蛋白4抗体
| 产品编号 | bs-8285R-FITC |
| 英文名称 | Anti-CRMP4/FITC |
| 中文名称 | FITC标记的脑衰蛋白反应调节蛋白4抗体 |
| 别 名 | Unc 33 like phosphoprotein; Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; DPYSL3; DRP 3; DRP3; LCRMP; TUC4; Ulip 1; ULIP; ULIP1; UNc 33 like phosphoprotein 1; Unc 33 like phosphoprotein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRMP4/DRP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The collapsin response mediator protein (CRMP) family of five cytosolic phosphoproteins are highly expressed throughout brain development. The functions of CRMPs encompass signal transduction in developmental guidance cues as well as multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, CRMPs remain expressed in structures that retain their capacity for differentiation and plasticity. The expression of CRMPs is altered in neurodegenerative diseases, and these proteins may have a role in the physiopathology of the adult nervous system. Function: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5 (By similarity). Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin (By similarity). Subcellular Location: Cytoplasmic. Cell projection, growth cone (By similarity). Note: Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. Post-translational modifications: Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Database links: Entrez Gene: 1809 Human Entrez Gene: 22240 Mouse Entrez Gene: 25418 Rat Omim: 601168 Human SwissProt: Q14195 Human SwissProt: Q62188 Mouse SwissProt: Q62952 Rat Unigene: 519659 Human Unigene: 428551 Mouse Unigene: 8180 Mouse Unigene: 93365 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
五个胞浆磷酸化蛋白的崩溃反应介体蛋白家族（CRMP）家族在整个脑发育过程中高度表达。CRMPS的功能包括信号转导在发育指导线索，以及多个细胞和分子事件涉及的细胞凋亡/增殖，细胞迁移和分化。在成年脑中，CRMPS的表达显著下调。然而，CRMPs仍然表现在保持其分化能力和可塑性的结构中。在神经退行性疾病中CRMPS的表达被改变，并且这些蛋白可能在成年神经系统的病理生理学中起作用。