FITC标记的δ-连环蛋白抗体
产品名称： FITC标记的δ-连环蛋白抗体
英文名称： Anti-delta 2 Catenin/FITC
产品编号： HZ-11679R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-delta 2 Catenin/FITC Conjugated antibody
FITC标记的δ-连环蛋白抗体
| 产品编号 | bs-11679R-FITC |
| 英文名称 | Anti-delta 2 Catenin/FITC |
| 中文名称 | FITC标记的δ-连环蛋白抗体 |
| 别 名 | Catenin (cadherin associated protein) delta 2; Catenin delta 2; Catenin delta-2; CTND2_HUMAN; CTNND 2; CTNND2; Delta catenin; Delta-catenin; GT 24; GT24; Neural plakophilin related arm repeat protein; Neural plakophilin related armadillo repeat protein; Neural plakophilin-related ARM-repeat protein; Neurojungin; NPRAP |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 信号转导 干细胞 细胞骨架 细胞外基质 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 133kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human delta 2 Catenin (951-1050aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: The Alpha-, Beta-, Gamma-, and Delta -catenins are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. Alpha-catenin interacts with E-cadherin associated protein and also associates with other members of the cadherin family, such as N-cadherin and P-cadherin. Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. Beta-catenin also complexes with the tumor suppressor protein APC. Gamma-catenin, also known as plakoglobin, is a protein that binds ?catenin and N-cadherin. Gamma-catenin interacts with presenilin 1 and is expressed in the brain. The gene encoding Gamma-catenin maps to human chromosome 5p15.2. A hemizygous loss of the gene encoding Gamma-catenin leads to the mental retardation associated with Cri-du-Chat syndrome. In addition, the transmembrane phosphatase PTPm associates with catenin/ cadherin complexes and may regulate complex signaling. Function: Functions as a transcriptional activator when bound to ZBTB33 (By similarity). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Subunit: Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33 (By similarity). Binds to PSEN1. Interacts with ARHGEF28. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Subcellular Location: Nucleus. Tissue Specificity: Predominantly expressed in brain. Post-translational modifications: O-glycosylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the beta-catenin family. Contains 9 ARM repeats. Database links: Entrez Gene: 1501 Human Entrez Gene: 114028 Rat Omim: 604275 Human SwissProt: Q9UQB3 Human SwissProt: O35116 Rat Unigene: 314543 Human Unigene: 15163 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
的α，β，γ和三角洲，连接蛋白是蛋白质，绑定到胞质尾（高conserved，intracellular E-cadherin的。钙粘蛋白catenin的配合物在一起，发挥了重要作用/ mediating细胞粘附。α-catenin的表达与E-cadherin蛋白interacts美联社和其他成员，所以Associates的钙粘蛋白家族，如N-钙黏蛋白和P -钙粘蛋白。β-连环蛋白在细胞质部分联营公司（E -钙粘蛋白，这是必要的功能作为一个粘附分子E-cadherin的。因此，β-连环蛋白的肿瘤抑制APC蛋白配合物。γ-连环蛋白，又称为plakoglobin蛋白，是一个认识？β-连环蛋白和N -钙粘蛋白。γ-连环蛋白与早老素1和一interacts表达在脑。基因编码的人力γ-连环蛋白地图染色体5p15.2.A基因编码的半合子损失γ-连环蛋白导致的精神发育迟滞与CRI杜聊天综合征。此外，一个跨膜钙粘蛋白-catenin）/磷酸酶复合物，比较优劣，可以和复杂的信号。