FITC标记的二氢嘧啶酶相关蛋白2抗体
产品名称： FITC标记的二氢嘧啶酶相关蛋白2抗体
英文名称： Anti-CRMP2/TOAD64/FITC
产品编号： HZ-1790R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CRMP2/TOAD64/FITC Conjugated antibody
FITC标记的二氢嘧啶酶相关蛋白2抗体
| 英文名称 | Anti-CRMP2/TOAD64/FITC |
| 中文名称 | FITC标记的二氢嘧啶酶相关蛋白2抗体 |
| 别 名 | Collapsin response mediator protein 2; Collapsin response mediator protein hCRMP 2; CRAM; CRMP 2; CRMP-2; CRMP2; DHPRP 2; DHPRP2; Dihydr pyrimidinase 2; Dihydropyrimidinase 2; Dihydropyrimidinase like 2; Dihydropyrimidinase like 2 long form; Dihydropyrimidinase related protein 2; Dihydropyrimidinase-related protein 2; DPYL 2; DPYL2; DPYL2_HUMAN; DPYSL 2; Dpysl2; DRP 2; DRP-2; DRP2; Musunc 33; Musunc33; N2A3; TOAD 64; TOAD64; ULIP 2 protein; ULIP-2; Ulip2; Unc-33-like phosphoprotein 2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 神经生物学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 62kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRMP2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Collapsin response mediator proteins (CRMPs) are cytosolic phosphoproteins involved in neuronal differentiation and axonal guidance. CRMP2 was previously shown to mediate the repulsive effect of Sema3A on axons and to participate in axonal specification. The CRMPs appear to play a complex role in axon growth as well as microtubule dynamics and axon induction. CRMPs localize to the lamellipodia and filopodia of axonal growth cones, suggesting a role in axon guidance. Moreover, CRMP2 is upregulated after axotomy, and appears to increase the formation of axon-type processes from hippocampal neurons. CRMP2 has been reported to bind tubulin dimers directly and modulate microtubule assembly. CRMPs have also been implicated in the pathogenesis of a paraneoplastic neurologic syndrome. Interaction studies have implicated phospholipase D2 (PLD2), the cytosolic tyrosine kinase Fes, and intersectin in CRMP function. Hyperphosphorylation of CRMP2 is an early event in the progression of Alzheimer's disease. Function: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (By similarity). Plays a role in neuron projection morphogenesis. Subunit: Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5 (By similarity). Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4 (By similarity). Interacts with CLN6. Subcellular Location: Cytoplasm. Tissue Specificity: Ubiquitous. Post-translational modifications: 3F4, a monoclonal antibody which strongly stains neurofibrillary tangles in Alzheimer disease brains, specifically labels DPYSL2 when phosphorylated on Ser-518, Ser-522 and Thr-509. Phosphorylation at Thr-514 by GSK3B abolishes tubulin-binding leading to destabilization of microtubule assembly in axons and neurodegeneration (By similarity). Phosphorylation by DYRK2 at Ser-522 is required for subsequent phosphorylation by GSK3B. Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. Database links: Entrez Gene: 1808 Human Entrez Gene: 12934 Mouse Entrez Gene: 25416 Rat Omim: 602463 Human SwissProt: Q16555 Human SwissProt: O08553 Mouse SwissProt: P47942 Rat Unigene: 173381 Human Unigene: 352648 Mouse Unigene: 475100 Mouse Unigene: 2889 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CRMP2是一种脑特异性蛋白，对于轴突生长和轴突-树突发育起到很重要的作用，CRMP2通过与微管蛋白二聚体结合并促进微管的组装来调控轴突的生长和分支 |
胶原蛋白反应介质蛋白（CRMPs）是参与神经元分化和轴突引导的细胞浆磷酸蛋白。CRMP2先前被证明介导Sema3A对轴突的排斥作用并参与轴突的规范。CRMPs在轴突生长、微管动力学和轴突诱导中起着复杂的作用。CRMP定位于轴突生长锥的片足和丝状体，提示其在轴突引导中的作用。此外，CRMP2在轴突切断后上调，并且似乎增加海马神经元轴突型过程的形成。CRMP2已被报道直接结合微管蛋白二聚体，并调节微管组装。CRMPS也参与副肿瘤性神经综合征的发病机制。相互作用研究提示磷脂酶D2（PLD2）、胞浆酪氨酸激酶FES和交叉蛋白在CRMP功能中的作用。CRMP2的过度磷酸化是阿尔茨海默病进展的早期事件。