FITC标记的转录起始因子TFIID亚基6抗体
产品名称： FITC标记的转录起始因子TFIID亚基6抗体
英文名称： Anti-TAF6/FITC
产品编号： HZ-12967R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TAF6/FITC Conjugated antibody
FITC标记的转录起始因子TFIID亚基6抗体
| 英文名称 | Anti-TAF6/FITC |
| 中文名称 | FITC标记的转录起始因子TFIID亚基6抗体 |
| 别 名 | E 70/85kD; TAF 6; TAF2E; TAF6 RNA polymerase II TATA box binding protein (TBP) associated factor 80 kD; TAF6 RNA polymerase II, TATA box binding protein associated factor,80kDa; TAFII 70; TAFII80; TATA box binding protein (TBP) associated factor RNA polymerase II E 70/85kD; TATA box binding protein (TBP) associated factor, RNA polymerase II,; TBP associated factor 6; Transcription initiation factor TFIID 70 kDa subunit; Transcription initiation factor TFIID subunit 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 73kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 2mg/1ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TAF6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex. Subcellular Location: Nuclear. Similarity: Belongs to the TAF6 family. Database links: Entrez Gene: 505638 Cow Entrez Gene: 6878 Human Entrez Gene: 21343 Mouse Entrez Gene: 288533 Rat Entrez Gene: 447818 Zebrafish Omim: 602955 Human SwissProt: Q58DG7 Cow SwissProt: P49848 Human SwissProt: Q62311 Mouse SwissProt: Q498R0 Rat SwissProt: Q63801 Rat Unigene: 489309 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
RNA聚合酶II启动转录需要70多个多肽的活性。协调这些活性的蛋白质是转录因子IID(TFIID)，它与核心启动子结合以正确定位聚合酶，作为组装转录复合物其余部分的支架，并且作为调节信号的通道。TFIID由TATA结合蛋白（TBP）和一组进化上保守的蛋白质组成，称为TBP相关因子或TAF。TAF可参与基础转录，作为辅活化子，在启动子识别中起作用，或修饰一般转录因子（GTF）以促进复杂的组装和转录启动。这个基因编码TFIID的一个较小亚基，它与TBP结合很弱，但与TFIID的最大亚基TAF1结合很强。选择性剪接导致多个转录变体。[ RefSeq 2010军提供]