FITC标记的Iroquois同源蛋白5抗体
产品名称： FITC标记的Iroquois同源蛋白5抗体
英文名称： Anti-IRX5/FITC
产品编号： HZ-9469R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-IRX5/FITC Conjugated antibody
FITC标记的Iroquois同源蛋白5抗体
| 产品编号 | bs-9469R-FITC |
| 英文名称 | Anti-IRX5/FITC |
| 中文名称 | FITC标记的Iroquois同源蛋白5抗体 |
| 别 名 | Homeodomain protein IRX-2A; Homeodomain Protein IRXB2; Iroquois Homeobox Protein 5; Iroquois-class homeodomain protein IRX-5; IRX2A; Irx5; IRX5_HUMAN; IRXB2. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 心血管 细胞生物 神经生物学 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 50kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IRX5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Function: Establishes the cardiac repolarization gradient by itsrepressive actions on the KCND2 potassium-channel gene. Requiredfor retinal cone bipolar cell differentiation. May regulatecontrast adaptation in the retina and control specific aspects ofvisual function in circuits of the mammalian retina (Bysimilarity). Could be involved in the regulation of both the cellcycle and apoptosis in prostate cancer cells. Involved incraniofacial and gonadal development. Modulates the migration ofprogenitor cell populations in branchial arches and gonads byrepressing CXCL12. Subcellular Location: Nucleus. DISEASE: Defects in IRX5 are the cause of Hamamy syndrome (HMMS)[MIM:611174]. A sydrome characterized by severe hypertelorism,upslanting palpebral fissures, brachycephaly, abnormal ears,sloping shoulders, enamel hypoplasia, and osteopenia with repeatedfractures. Additional features include myopia, mild to moderatesensorineural hearing loss, gonadal anomalies, and borderlineintelligence. Similarity: Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding domain. Database links: Entrez Gene: 10265 Human Entrez Gene: 54352 Mouse Entrez Gene: 498918 Rat Omim: 606195 Human SwissProt: A2RRB5 Human SwissProt: P78411 Human SwissProt: Q9JKQ4 Mouse Unigene: 435730 Human Unigene: 101153 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
通过对KCND2钾通道基因的抑制作用建立心脏复极梯度。视网膜锥体双极细胞分化所需。可以调节视网膜中的对比适应，并控制哺乳动物视网膜的电路（视相似度）的视觉功能的特定方面。可能参与前列腺癌细胞周期和凋亡的调控。