FITC标记的肝癌衍生生长因子相关蛋白3抗体
产品名称： FITC标记的肝癌衍生生长因子相关蛋白3抗体
英文名称： Anti-HDGFRP3/FITC
产品编号： HZ-16464R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749
- 传真 : 021-60345367
- 邮箱 : www.shzbio.net
Rabbit Anti-HDGFRP3/FITC Conjugated antibody
FITC标记的肝癌衍生生长因子相关蛋白3抗体
| 英文名称 | Anti-HDGFRP3/FITC |
| 中文名称 | FITC标记的肝癌衍生生长因子相关蛋白3抗体 |
| 别 名 | CGI 142; HDGF 2; HDGF-2; HDGF2; HDGFRP 3; Hdgfrp3; HDGR3_HUMAN; Hepatoma derived growth factor 2; Hepatoma derived growth factor related protein 3; Hepatoma-derived growth factor 2; Hepatoma-derived growth factor-related protein 3; HRP 3; HRP-3; HRP3. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 神经生物学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 23kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HDGFRP3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Hepatoma derived growth factor (HDGF) is the original member of a family of polypeptides designated HDGF-related proteins (HRPs). HDGF was initially characterized as a secreted mitogen from the Huh-7 human hepatoma cell line. This nuclear targeted vascular smooth muscle cell mitogen (VSM) is a heparin-binding protein that is highly expressed in tumor cells, where it stimulates proliferation. HDGF is also reported to be involved in organ development and lung remodeling after injury by promoting proliferation of lung epithelial cells. During development, HDGF expression is high in the nucleus and cytoplasm of smooth muscle and endothelial cells. The HRP family contains four proteins, HRP-1, HRP-2, HRP-3 and HRP-4. HRP-1 and HRP-4 are expressed only in testis, while HRP-2 is widely expressed in different tissues. HRP-3 can be found solely in the nervous system. Specifically it is strongly expressed in bulbus, olfactorius, piriform cotrex and amygdala complex, while HRP-2 in brain is located in the the thalamus, prefrontal and parietal cortex, neurohypophysis and cerebellum. In the central nervous system, HRPs play a role in neuron proliferation and cell survival. Function: Enhances DNA synthesis and may play a role in cell proliferation. Subcellular Location: Nucleus. Tissue Specificity: Detected in testis, heart, spinal cord and brain. Similarity: Belongs to the HDGF family. Contains 1 PWWP domain. Database links: Entrez Gene: 50810 Human Entrez Gene: 29877 Mouse Entrez Gene: 252941 Rat SwissProt: Q9Y3E1 Human SwissProt: Q9JMG7 Mouse SwissProt: Q923W4 Rat Unigene: 513954 Human Unigene: 392934 Mouse Unigene: 17383 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
肝癌衍生生长因子（HDGF）是HDGF相关蛋白（HRP）的多肽家族的原成员。HDGF最初是从HUH-7人肝癌细胞系分泌的有丝分裂原的特征。这种核靶向血管平滑肌细胞有丝分裂原（VSM）是一种肝素结合蛋白，在肿瘤细胞中高度表达，刺激细胞增殖。据报道，HDGF通过促进肺上皮细胞增殖而参与损伤后器官发育和肺重构。在发育过程中，HDGF在平滑肌和内皮细胞的细胞核和细胞质中表达较高。HRP家族含有四个蛋白，即HRP－1、HRP－2、HRP－3和HRP－4。HRP－1和HRP－4仅在睾丸中表达，而HRP－2在不同组织中广泛表达。HRP -3只能在神经系统中找到。HRP-2主要分布于丘脑、前额皮质、顶叶皮质、神经垂体和小脑。在中枢神经系统中，HRP在神经元增殖和细胞存活中起作用。