CNTF Receptor alpha,睫状神经营养因子受体α抗体

产品编号HZ-1516R
英文名称CNTF Receptor alpha
中文名称睫状神经营养因子受体α抗体
别 名CNTFR Alpha; Ciliary neurotrophic factor receptor alpha; CNTFR Alpha; CNTFR; Ciliary neurotrophic factor receptor alpha; Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR Alpha; CNTFR; CNTFR-alpha; CNTFR.
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep,
CNTF Receptor alpha,睫状神经营养因子受体α抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量36kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CNTFR Alpha
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CNTF Receptor alpha,睫状神经营养因子受体α抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011].

Function:
Binds to CNTF. The alpha subunit provides the receptor specificity.

Subunit:
Heterotrimer of the alpha subunit, LIFR and IL6ST.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Tissue Specificity:
Nervous system and skeletal muscle.

CNTF Receptor alpha,睫状神经营养因子受体α抗体Similarity:
Belongs to the type I cytokine receptor family. Type 3 subfamily.
Contains 2 fibronectin type-III domains.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Gene ID:
1271

Database links:
Entrez Gene: 442941 Dog
Entrez Gene: 1271 Human
Entrez Gene: 12804 Mouse
Entrez Gene: 313173 Rat
Omim: 118946 Human
SwissProt: Q71DR4 Dog
SwissProt: P26992 Human
SwissProt: O88507 Mouse
SwissProt: Q08406 Rat
Unigene: 129966 Human
Unigene: 425178 Mouse
Unigene: 55036 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

神经生物学相关蛋白（Neurobiology）
CNTFRα是CNTF的特异性结合蛋白。在周围神经损伤后CNTF与其受体有其特异的变化模式及调节机制，对神经损伤后的再生有重要作用。

产品图片

Tissue/cell: rat muscle tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-CNTF Receptor alpha Polyclonal Antibody, Unconjugated(HZ-1516R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining