分子量:25.6 kDa

纯度:>95% as determined by SDS-PAGE.

内毒素:Less than 1.0 EU per μg of the Human IFN-alpha/beta R2, His Tag by the LAL method.

Buffer:PBS, pH7.4

生物活性:

产品特性:Human IFN-alpha/beta R2, His Tag is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 25.6 kDa. The predicted N-terminus is Ile 27. The reducing (R) protein migrates as 40-50 kDa in SDS-PAGE  due to glycosylation.

产品背景:Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to thetype II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.