Tenascin R,腱糖蛋白R抗体

产品编号HZ-11068R
英文名称Tenascin R
中文名称腱糖蛋白R抗体
别 名Janusin; Restrictin; TenascinR; Tenascin-R; Tenascin R (restrictin, janusin); Tenascin-R; TENR_HUMAN; TN-R; Tnr; TNR; TENR; MGC149328.
说 明 书0.1ml 0.2ml
研究领域发育生物学 神经生物学 信号转导 细胞粘附分子 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
Tenascin R,腱糖蛋白R抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量146kDa
细胞定位细胞外基质 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human TNR/Tenascin-R
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Tenascin R,腱糖蛋白R抗体PubMedPubMed
产品介绍background:
The Tenascin family of extracellular matrix proteins includes Tenascin (also designated cytotactin or Tenascin-C), Tenascin-R (also designated Restrictin or Janusin) and Tenascin-X. Tenascin proteins function as substrate-adhesion molecules (SAMs) and are involved in regulating numerous developmental processes, such as morphogenetic cell migration and organogenesis. The Tenascin family proteins arise from various splicing events in the region of coding for FNIII repeats. Tenascin and Tenascin-X are expressed in several tissues during embryogenesis, and in adult tissues undergoing active remodel-ing such as healing wounds and tumors. Tenascin-R (TN-R) is expressed on the surface of neurons and glial cells.

Function:
Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance.

Subunit:
Forms oligomers. Interacts with CNTN1, TNC, and FN1. Interacts with BCAN and ACAN in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity).

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tenascin R,腱糖蛋白R抗体Tissue Specificity:
Brain specific.

Post-translational modifications:
Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.

Similarity:
Belongs to the tenascin family.
Contains 5 EGF-like domains.
Contains 1 fibrinogen C-terminal domain.
Contains 9 fibronectin type-III domains.

Database links:
Entrez Gene: 3371 Human
Entrez Gene: 21923 Mouse
Entrez Gene: 116640 Rat
Omim: 187380 Human
SwissProt: P24821 Human
SwissProt: Q80YX1 Mouse
SwissProt: B2LYI9 Rat
Unigene: 143250 Human
Unigene: 454219 Mouse
Unigene: 980 Mouse
Unigene: 12723 Rat

Tenascin R,腱糖蛋白R抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.