FITC标记的磷酸化α型-过氧化酶活化增生受体抗体
产品名称： FITC标记的磷酸化α型-过氧化酶活化增生受体抗体
英文名称： Anti-phospho-PPAR alpha (Ser12)/FITC
产品编号： HZ-
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-PPAR alpha (Ser12)/FITC Conjugated antibody
FITC标记的磷酸化α型-过氧化酶活化增生受体抗体
| 英文名称 | Anti-phospho-PPAR alpha (Ser12)/FITC |
| 中文名称 | FITC标记的磷酸化α型-过氧化酶活化增生受体抗体 |
| 别 名 | PPAR alpha (phospho-Ser12); PPAR alpha (phospho-S12); p-PPAR alpha (Ser12); p-PPAR alpha (S12); hPPAR; MGC2237; MGC2452; NR1C1; Nuclear receptor subfamily 1 group C member 1; Peroxisome Proliferator Activated Receptor alpha; PPAR; PPAR alpha; PPARA; OTTHUMP00000197740; OTTHUMP00000197741; Peroxisome proliferator-activated receptor alpha; PPAR-alpha; PPARA_HUMAN; PPARalpha. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 52kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human PPAR alpha around the phosphorylation site of ser12 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Peroxisome proliferators are nongenotoxic carcinogens which are purported to exert their effect on cells through their interaction with members of the nuclear hormone receptor family, termed Peroxisome Proliferator Activated Receptors (PPARs). Nuclear hormone receptors are ligand dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate ligand. Studies indicate that PPARs are activated by peroxisome proliferators such as clofibric acid, nafenopin, and WY-14,643, as well as by some fatty acids. It has also been shown that PPARs can induce transcription of acyl coenzyme A oxidase and cytochrome P450 A6 (CYP450 A6) through interaction with specific response elements. PPAR alpha is activated by free fatty acids including linoleic, arachidonic, and oleic acids. Induction of peroxisomes by this mechanism leads to a reduction in blood triglyceride levels. PPAR alpha is expressed mainly in skeletal muscle, heart, liver, and kidney and is thought to regulate many genes involved in the beta-oxidation of fatty acids. Activation of rat liver PPAR alpha has been shown to suppress hepatocyte apoptosis. PPAR alpha, like several other nuclear hormone receptors, heterodimerizes with retinoic X receptor (RXR) alpha to form a transcriptionally competent complex. Function: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Subunit: Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with AKAP13, LPIN1 and PRDM16. Also interacts with PPARBP coactivator in vitro. Interacts with CITED2; the interaction stimulates its transcriptional activity (By similarity). Interacts with NCOA3 and NCOA6 coactivators. Interacts with ASXL1 AND ASXL2. Subcellular Location: Nucleus. Tissue Specificity: Skeletal muscle, liver, heart and kidney. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. Database links: Entrez Gene: 5465 Human Entrez Gene: 19013 Mouse Entrez Gene: 25747 Rat Omim: 170998 Human SwissProt: Q07869 Human SwissProt: Q6I9S0 Human SwissProt: P23204 Mouse SwissProt: Q542P9 Mouse SwissProt: P37230 Rat Unigene: 103110 Human Unigene: 710044 Human Unigene: 212789 Mouse Unigene: 9753 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
过氧化物酶体增殖物是非毒性致癌物，据称通过它们与核受体家族成员的互作用而发挥作用，称为过氧化物酶体增殖物激活受体（PPARs）。核受体是依赖于配体的胞内蛋白，通过结合适当配体激活后，通过特异性DNA序列刺激特定基因的转录。研究表明，过氧化物酶体增殖物，如氯维甲酸、萘烯醇和WY-1464 3，以及一些脂肪酸，激活PPAR。还表明，PPARs可以诱导酰基辅酶A氧化酶和细胞色素P450A6（CYP450A6）通过与特异性应答元件的相互作用转录。PPARα由游离脂肪酸激活，包括亚油酸、花生四烯酸和油酸。通过这种机制诱导过氧化物酶体导致血液甘油三酯水平降低。PPARα主要表达于骨骼肌、心脏、肝脏和肾脏，被认为是调节脂肪酸β-氧化中涉及的许多基因。活化大鼠肝脏PPARα已被证明能抑制肝细胞凋亡。PPARα与其他几种核受体一样，与维甲酸X受体（RXR）α异源二聚，形成转录能力复合体。